Harry Moleman is the main adversary in The Mole, the Mob, and the Meatball and returns in some later episodes.
Harry Moleman was originally sent by the police to infiltrate the Toy Mafia. However, he switched sides and went on to become their leader, adopting the name Don Ted E. Bear. In The Mole, the Mob, and the Meatball, he hoped to gain much power through a ploy involving hypnotic bear toys but was thwarted by Sam & Max, who destroyed his toy factory.
He also has a cameo in Culture Shock, when at the home you can find a poster called "Harry Moleman, The life Story"
After being presumed dead when the factory exploded he later made a reappearance manning the tourist shop on the moon. At that point he was revealed to be much smaller and weaker than his Ted E. Bear suit had made him appear earlier. During Night of the Raving Dead he made a failed bid for Sybil's affection. In What's new, Beelzebub? he was revealed to have taken a new job as Death.
In Season Three, Harry works for Dr. Momma Bosco as her assistant (though she never actually hired him). He was later captured by General Skun-ka'pe, but escaped. In Beyond the Alley of the Dolls, Harry takes part in a seance to bring Dr. Momma Bosco's ghost back. Sam and Max were able to do so by tricking Harry into believing he had a conversation with his recently-deceased Uncle Morty. Later in the episode, he is heard from the inside of the Statue of Liberty, looking for his uncle's hidden stamp collection.
Zombies (because they break things)